Understanding Lupus and Auto‐Immune Diseases

Air Pollution and its Effects on Autoimmune Diseases

Role of Interleukin-37 in Inflammatory and Autoimmune Diseases

Interleukin-1 family 7 (IL-1F7) is a novel member of IL-1F cytokines. IL-1F7 is more commonly known as IL-37. IL-37 join the α-subunit of the IL-18 receptor, or IL-18 binding protein (IL-18BP), and binding of these proteins can enhance the IL-18 suppression. IL-37 also translocates to the cell nucleus and affects gene transcription. IL-37 inhibits the phosphorylation of p38 mitogen-activated pr...

CANINE & FELINE AUTOIMMUNE & IMMUNE MEDIATED DISEASES: DERMATOLOGY AN UPDATE PART 2 Rod A.W. Rosychuk DVM, DACVIM Selected Lupus and Lupus-like Diseases Discoid Lupus Erythematosus (DLE)

DLE in dogs is seen primarily in younger dogs (2–4 years of age) as a depigmenting and inflammatory disease of the nasal planum, bridge of the nose, periocular region, mucocutaneous areas of the lips, and occasionally the pinna. A variant of the disease (or perhaps a different disease?) is seen primarily in Australian shepherds and “white” dolicocephalic dogs, resulting in very severe atrophy a...

Leptin and Autoimmune Diseases

Introduction: Leptin, an anti-obesity hormone, is also a regulator of the immune response whichsends important signals regarding the metabolic status and immune system function. Thishormone/cytokine can affect the secretion of acute phase proteins such as Interleukin-1 and TNF-αand facilitate communication between nutrition and Th1 immune response so that when the foodintake...

Epigenetics and Autoimmune Diseases

Epigenetics is defined as the study of all inheritable and potentially reversible changes in genome function that do not alter the nucleotide sequence within the DNA. Epigenetic mechanisms such as DNA methylation, histone modification, nucleosome positioning, and microRNAs (miRNAs) are essential to carry out key functions in the regulation of gene expression. Therefore, the epigenetic mechanism...